• Mouse monoclonal antibody to HB-EGF
• Application: WB, ELISA
• Species reactivity: Human,mouse
Diphtheria toxin receptor, diphtheria toxin receptor (heparin-binding EGF-like growth factor), diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor), DT-R, HB-EGF, HBEGF, Heparin-binding EGF-like growth factor, heparin-binding epidermal growth factor, Proheparin-binding EGF-like growth factor
Heparin binding epidermal-like growth factor (HB-EGF), a ligand of the EGF receptor (EGFR) and can also bind to heparin sulfate proteoglycans on the cell surface. The HB-EGF gene encodes a 208 amino acid precursor containing a signal peptide and transmembrane domain. Mature HB-EGF is a soluble protein 86 amino acids in length and results from the enzymatic cleavage of the membrane bound precursor. The membrane-bound form of HB-EGF has been identified as the diphtheria toxin receptor.